People in Research

Misty Noble

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Advisor: Buddy Ratner

Department/status: 2nd year in the BioEngineering PhD Program

Project overview: Ultrasound Responsive Drug Delivery System

Project details:
An ultrasound-responsive drug delivery system is being developed comprising of a drug-loaded polymeric monolith [poly(2-hydroxyethyl methacrylate) [p(HEMA)]] is coated with an ultrasound-responsive self-assembled monolayer of methylene chains. The resulting coating is relatively impermeable, and the ordered methylene chains forms an ultrasound-activated on-off switch in controlling drug release on demand, while keeping the drug inside the polymer carrier in the absence of ultrasound. The ultrasound-controlled release of antibiotics, such as ciprofloxacin, on biofilms under flow conditions are currently being investigated.

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